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Z51: Physics Enabled Medical Devices

Room 321

Sponsoring Units: GMEDChair: Stephen Russek, NIST BoulderSession Type:
  • Invited
  • Undergrad Friendly

Fri. March 10, 11:30 a.m. – 12:06 p.m. PST

Room 321

Magnetic Resonance Imaging (MRI) offers a natural, quantitative way of characterizing soft tissues in health and disease. With the development of the MRI field, the quantitative aspect was dropped in favor of qualitative, contrast-based imaging approaches. In recent years a renewed interest in quantitation in MRI has emerged, enabled by the development of new ideas for shortening the length of qMRI scans rivaling contrast-based approaches. The absolute categorization of tissue is based on quantitative biomarkers established in clinical studies and trials. The major biomarkers are based on MR tissue properties - longitudinal T1 and transverse T2 relaxation times, diffusion properties – Apparent Diffusion Coefficient (ADC), etc. A significant obstacle in adopting clinical qMRI methodologies is the variability of the quantitative output within and across manufacturers. CaliberMRI (CMRI) is on a quest to standardize scanner lateral and longitudinal performance using quantitative Reference MRI Mimics. The mimics are standardized by the NIST and qCal, a CMRI software platform for comprehensive QA/QC analysis. We will present a use case of standardization of ADC as a breast cancer biomarker in neoadjuvant therapy monitoring in I-SPY2 clinical trial.

Presented By

  • Todor Karaulanov (CaliberMRI, Inc.)


  • Todor Karaulanov (CaliberMRI, Inc.)
  • Chamni Jayarathna (CaliberMRI)
  • David Van Wie (CaliberMRI)
  • Jessica E Gibbs (UCSF)
  • Nu N Le (UCSF)
  • David Newitt (UCSF)
  • Bonnie N Joe (UCSF)
  • Nola M Hylton (UCSF)
  • Lisa Wilmes (UCSF)